ATSDR Issues Final PFAS Toxicological Profile

The Agency for Toxic Substances and Disease Registry (ATSDR) has released its, “Toxicological Profile for Perfluoroalkyls,” PFAS final report. The report generally preserves the minimal risk levels (MRLs) it proposed in the 2018 draft report. The report discusses information on ten PFAS (PFOS, PFOA, PFHxS, PFNA, PFBA, PFHpA, PFDA, PFDoDA, and FOSA) that have been measured in the serum collected from a representative US population 12 years of age and older in the National Health and Nutrition Examination Survey as well as two compounds (PFBA and PFHxA) that have been identified in other monitoring studies. For at least one compound (PFOS), EPA’s 2016 lifetime chronic exposure and health advisory is based on a less strict reference dose of 2×10^-5 mg/kg/day, compared to ATSDR’s MRL of 2×10^-6 mg/kg/day. In addition, ATSDR also set limits for PFHxS and PFNA, for which EPA also has no corresponding reference dose. For more information and to view the report, visit the website here.