EPA Requests Comments on Draft IRIS Toxicological Review of PFBA and Requests Panel Nominations for Five PFAS Assessments

EPA has announced the availability of the Draft IRIS Toxicological Review of Perfluorobutanoic Acid (PFBA) and related compound Ammonium Perfluorobutanoic Acid for a 60-day public comment and review period. At the same time, EPA has announced a request for nominations of experts to an IRIS Peer Review Panel that will review the assessments for PFBA and four other PFAS – Perfluorodecanoic Acid (PFDA), Perfluorononanoic Acid (PFNA), Perfluorohexanoic Acid (PFHxA), Perfluorohexanesulfonic acid (PFHxS).

The PFBA Toxicological Review evaluates human and animal studies to derive toxicity values for cancer and noncancer health effects resulting from chronic exposure. The systematic review protocol and dose-response analyses for these assessments has also been updated in response to public comments. The protocol includes a summary of why these PFAS were prioritized for evaluation, a description of the objectives and specific aims of the assessments, draft PECO (Populations, Exposures, Comparators, and Outcomes) criteria, and identification of key areas of scientific complexity. For more information, read the Federal Register Notices for the PFBA Toxicity Review and Expert Nominations, and visit the EPA IRIS website.